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But Benita stood by her man and, she said, tried to help him through a tough time. Scientific pioneer, superstar surgeon, miracle worker thats how Paolo Macchiarini was known for several years. The plastic trachea that Yesim Cetir received disfigured her and made her last three years in life basically like torture, said Bosse Lindquist, a documentarian who broke the story in Sweden about Dr. Macchiarini in a television series, The Experiment.. Even the jewelry he had given her was fake. In 2017, after another hospital said everything possible had been tried, she felt desperate. Paolo Macchiarini traveled to Illinois to operate on toddler Hannah Warren, who was born without a trachea in 2013. His operation was on June 9, 2011, at the Karolinska University Hospital, where he received the upgraded plastic trachea made at University College London. But that, and the fact that he had multiple cell phones for different countries, she chalked up to his demanding job and constant international travel. The other side is flat and mobile to move air to the lungs. An alarmingly wide gap has grown between what we expect from stem cells and what they deliver. And then there are the surgeons on Dr. Death. Next month, she will turn 57. Alexander started a problem with the specialist at this time. He reportedly lied on his CV and research papers to trick patients, causing almost all those who received his inventive trachea transplants (using their own bone marrow cells for organ functionality) to lose their lives. Dr. Gerdin said Dr. Macchiarini was allowed to continue his procedures for so long because the Karolinska Institute and its hospital allowed him to do so. Delaeres damning criticisms appeared in major medical journals, including the Lancet, but werent taken seriously by Karolinskas leadership. Selena died in a hospital due to a loss of blood and cardiac arrest, two weeks before her 24th birthday. According to Macchiarini and his colleagues, her artificial organ was well on the way to looking and functioning liked a natural one. The other patients were treated at hospitals in Barcelona, Florence, London, Moscow, Krasnodar, Chicago and Peoria. At first, they just connected as friends. However, he eventually found out about his previous associations. ONE Super Series A 29-year old woman from New Brunswick, New Jersey, posed as a high school student and attended classes for four days before she was caught and arrested. Paolo Macchiarini rode groundbreaking surgeries to global fame, but patients died anyway. Born in 1984, Zhadyra Iglikova suffered from tracheostomy following a car accident. So far he has not been prosecuted in any of those countries. Now his reputation lies in tatters. Last year, however, the dream soured, exposing an ugly reality. That drama began about a decade ago when Dr. Paolo Macchiarini, working at Swedens famed Karolinska Institute, garnered headlines and accolades for replacing damaged tracheas with plastic tubes seeded with patients stem cells that he cultivated in devices called bioreactors. They will especially examine the judges decision that Macchiarini couldnt be held responsible for what happened to Andemariam and Lyles because he acted in distress, according to the courts statement. He is still licensed to practice medicine in Europe. Why are people hesitant to trust a COVID-19 vaccine? The transplants, performed on patients from the United States and other countries, were heralded as inaugurating a regenerative medicine revolution. Besides which, compassionate concerns dont override the basic principles of patient safety and informed consent. Video Benita Alexander on attending Paolo Macchiarinis criminal She told CrimeFeed that, looking back, it seemed odd to her she had not met many of Paolo's close friends in Barcelona. Benita Alexander and Paolo Macchiarini in Venice, Italy [Investigation Discovery]. Jakarta If the Pope was planning to marry two divorcees, surely it would be huge global news? At any rate, some of his most powerful friends were themselves Nobel judges until, with his fall from grace, they fell too. Any replacement trachea must be rigid or itll collapse like a straw in a McDonalds milkshake, Dr. Genden said. A panel of judges unanimously ruled that the interventions were not in accordance with science and proven experience, according to a statement released today. Gretchen Vogel is a contributing correspondent for Science magazine based in Berlin, Germany. He was one of the best con-men I have ever come across, he added. She considered backing out. Not only that, they later covered it up.. More than a decade ago, Macchiarini became a superstar in the field of medicine when he implanted the worlds first bioartificial windpipe, a plastic structure that used the patients stem cells to reduce the risk of organ rejection. In their view, Macchiarini was certainly engaged in clinical research. By 2011, he was working in Sweden at one of the worlds most prestigious medical universities, the Karolinska Institute, whose professors annually select the winner of the Nobel prize in physiology or medicine. The nine-centimeter transplant replaced all but two centimeters of her trachea. It relieved a little bit of burden from him.. Reports of their success always seemed like hot air to him. How a star surgeon's personal and professional lives converged (The patient who survived had the implant removed.). The coronavirus pandemic will most likely create more cases because many Covid-19 patients have needed weeks on ventilators. George Floyd Does the heat of stem cell research the high levels of funding, prestige and media coverage it enjoys somehow encourage fraud? In the months and years following their respective surgeries, all of them except Dmitri Onogda have passed away due to post-operative complications. This argument didnt wash with those who later investigated the case. Even the jewelry he had given her was Alexander eventually fell in love with the surgeon, and in 2014, he proposed to her, and they started planning a lavish wedding for the following year. She would later discover that the woman in Barcelona had been living with Paolo for years, but that there were several other women in his life as well. The pope, the palace, the world leaders, the famous tenor they were all fantasies. The verdict is the latest development in Macchiarinis stunning fall from grace. Some answers have emerged from the official inquiries into the Karolinska Institute and the Karolinska University hospital. The court had to apply the intentional indifference standard for the assault charges, he says, which is difficult to prove. There are also plenty of desperate patients who believe because theyve been told countless times that stem cells are the cure, and who cannot wait any longer for mainstream medicine. 2023 Cinemaholic Inc. All rights reserved. How we can build a clean and renewable future. When the blood vessels were finally connected, the donor trachea began bleeding. Back in New York, Benita found herself unable to stop thinking about Paolo's patients. Because immunosuppressant drugs are required to prevent rejection of the transplant, cancer patients would be eligible only if free of cancer for five years, Dr. Genden said. Benita Alexander on attending Paolo Macchiarinis criminal trial in Sweden Alexander said she attended Macchiarini's trial for closure, seven years after she was Please try again later. In June 2016, the public prosecutor's office began investigating Paolo on suspicion of manslaughter and grievous bodily harm based on the material leading to the deaths of the three patients operated on in Sweden. Benita first met Paolo at the bar at Bostons Mandarin Oriental hotel in February 2013, when she was helping coordinate an interview for an NBC special on regenerative medicine. A few years ago, Japans Haruko Obokata pulled a similar con when she announced to the world a new and simple and fake method of turning ordinary body cells into stem cells. Allegations also emerged that the risky procedure was performed on at least one person who was not critically ill at the time. Tokyo And fooled almost everyone. Ultimate Fighting Championship In 2015, the Karolinska Institute hired an independent investigator named Dr. Bengt Gerdin to look into the Macchiarini situation, per the Times. However, the serious complications that Castillo suffered were, for a long time, kept very quiet. Benita Alexander thought that she was living a real-life fairy tale when she met her fianc, Paolo Macchiarini. Paolo was a world-renowned surgeon who spoke six languages, mingled with the global elite, and resembled George Clooney. Any woman would swoon for such a catch! We now know that wasnt true. Cardiothoracic surgeon Matthias Corbascio, one of Macchiarinis former colleagues at KI who first raised questions about the work, describes it as terrible and insane. The court basically gave him a slap on the wrist, says Corbascio, who is now at the University of Copenhagen. He is from Italy. Nearly all of those patients have died. Stem-cell scientist Dr. Paolo Macchiarini was accused of wrongdoing during operations on three people between 2011 and 2014. It showed department heads and colleagues that they should give Macchiarini special treatment.He could do pretty much as he pleased. Disgraced Italian surgeon convicted of criminal harm to stem cell Michigan And difficult to jump off. Paolo Macchiarini Donald Trump California KI fired Macchiarini in March 2016, 2 months after the Swedish documentary came out. The court said the penalty was a suspended sentence, but did not specify how long the sentence would be if imposed. But they found prosecutors didnt prove Macchiarini was indifferent to the injuries or suffering that the surgeries might cause, the standard required for aggravated assault. But after Alexander learned that Pope Francis was scheduled to visit South America at the time of their wedding, she confronted Macchiarini about his claims. He took the medical world by storm when he built and transplanted the worlds first bioartificial windpipe two years earlier. Paolo proposed to her on Christmas Day in 2013. But even if his days had been numbered, this didnt necessarily justify what Macchiarini put him through. In 2018, KI finally released the findings of its second investigation, which confirmed he had committed misconduct. This guy mutilated people., Between 2011 and 2014, Macchiarini implanted artificial windpipes in at least eight patients in Sweden, the United States, and Russia. Dr. Paolo Macchiarini became a star by creating a bioartificial windpipe. One biomedical researcher has documented a total of 20 tracheal regeneration procedures by Macchiarini in Russia, Spain, Britain, and the United States, as well as Sweden. Because mucus would clog her tube, she was constantly suctioning, constantly worried about her airway, and it becomes overwhelming, Dr. Genden said, like being held down in a swimming pool. Karolinska Institute announced in February 2016 that it would not renew his research contract, which was due to expire in November 2016, then terminated the contract in December 2016. As per They should be. Since this was radically new, Macchiarini and his colleagues should have tested it on animals first. Euan Ward reported from London, and Christina Anderson from Bastad, Sweden. Source: ABC Article continues below advertisement His relationship with Benita, Still, noting that previous attempts didnt show documented success, he cautioned that longer-term results were needed before the technique should be embraced, adding, Lets see how it works and how you can do it in more patients.. While there isnt enough data to actually prove this, we do have some key indicators. None have been forced to hold full and independent inquiries. He could see no real evidence that the windpipe scaffolds were becoming living, functioning airways in which case, they were destined to fail. A surgeon who just a decade ago was celebrated around the globe as a pioneer in stem cell transplants has been convicted of one count of causing bodily harm, a felony, in a Swedish court. fall of a celebrity scientist In 2013, the hospital halted future operations with synthetic trachea and opted to not extend Macchiarinis contract. But hes lost his reputation, and thats more important.. Paolo Macchiarini But as the big day approached, Alexander saw these plans unravel, and finally realised that her lover had lied about almost everything. Every patient had another, nonlethal option, Pierre Delaere, a trachea expert at KU Leuven and an early critic of Macchiarini, said in an email to Science. Even so, it wasnt until 2016 that the Karolinska Institute declined to renew his contract. Dr. Genden examines the new trachea by inserting a scope in a hole he left in her neck, which hell eventually close. When you implant a synthetic trachea you have one certainty, and that is that the patient will die as a result of it, Delaere says in the email. Vanity Fair also later discovered that several of Paolo's other statements were false, including his claims about having been an associate professor at the University of Pisa. The Karolinska Institute declined to comment for this article, noting only that Dr. Macchiarinis sentence may be appealed. Alexander said that Macchiarini told her he was still married to his wife because they were Catholic but were separated. We have estimated Paolo Macchiarini's net worth , money, salary, income, and assets. Previously considered a pioneer for using both biological and synthetic scaffolds The mild sentence comes as a disappointment to Macchiarinis critics. You cant justify doing experimental surgery and immunosuppression when you see something else that looks perfect, so you realize, wow, were out of business., As Dr. Macchiarinis work drew criticism, Dr. Genden revived his idea, but was uncertain about trying it. Only four months after Macchiarini operated on Claudia Castillo, his results provisional but very positive were published online by the Lancet. The surgeons defense attorney, Bjrn Hurtig, said his client was considering an appeal. 2023 Guardian News & Media Limited or its affiliated companies. By using a patients own cells, Dr. Macchiarini sought to rectify an age-old problem with transplants involving donated organs, which the body sometimes rejects as foreign tissue. Andemariam Beyene met up with Macchiarini in Iceland a year after his operation but later died Two more patients were also given transplants at the Karolinska When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. Dr. Macchiarini received a conditional, or suspended, sentence, and was acquitted of assault charges related to two other patients who had also received the artificial organs from him at the Swedish facility. 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The Karolinska University Hospital suspended Dr. Macchiarinis contract as a surgeon in 2013, but the affiliated Karolinska Institute kept him on until 2016 even as the scandal over his work spread, according to a timeline on the institutes website. 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The trachea has been characterized as a simple tube, but its very complex, Dr. Delaere said. On May 13, Alexander left her job. But the judges decided that, because the initial prognoses for Andemariam and Lyles were so grim without surgery, Macchiarini could not be held criminally responsible in those cases. This went on for three years until, just recently, Grinnemo was cleared of all wrongdoing. Her transformation follows a groundbreaking experimental procedure she underwent in January: the first time, medical experts believe, a donor trachea has been successfully directly transplanted into another person. Paolo was a world-renowned surgeon who spoke six languages, mingled with the global elite, and resembled George Clooney. Dr. Paolo Macchiarini at the Karolinska Institute in Stockholm in 2013. According to The New York Times, Macchiarini is an Italian surgeon who was found criminally liable this June for causing felony bodily injury to a Turkish woman named Yesim Cetir, a patient who had received one of his 3D-printed windpipes and later died. In the case of Cetir, he should have known the risk of complications was higher than the expected benefit, the judges ruled. Not just that, Paolo was also entangled in several other controversies. The couple had traveled extensively, but there were a The secret sauce in his approach, he said, is transplanting not just the donor trachea but also its attached esophagus (food tube), thyroid gland and thyroid arteries. At the time, Macchiarini was working at Swedens Karolinska Institute, which awards the Nobel Prize in Physiology or Medicine every year. She became close to Paolo as she opened her heart to him about how hard it was for her daughter, then nine years old, to lose her father. For other cases, though, doctors say the approach seems promising. Gerdins report, released in May 2015, concluded Macchiarini was guilty of misconduct, but university administrators rejected that conclusion 3 months later, arguing Macchinarini and his co-authors had satisfactorily countered the issues Gerdin raised. The theory was simple: let the body do most of the work. That meant the donor trachea was accompanied by a blood supply that Dr. Genden connected to Ms. Seins blood vessels. Investigations by the hospital and the Karolinska Institute revealed that issues with Dr. Macchiarinis work had been covered up. Claudia Castillo with Dr Paolo Macchiarini. Yet because of the ensuing complications, she had to receive a tracheoplasty in April 2011 and another cadaveric trachea graft in 2018. Massachusetts Likewise the whole idea of a wedding: Macchiarini was still married to his wife of 30 years. In September, a Swedish prosecutor indicted him on aggravated assault charges related to three trachea transplants. Swedish television broadcast a three-part expos of Paolo's work called Experimenten, which argued that the artificial windpipes did more harm than good and were actually rotting away inside his patients' bodies. No one is more powerless than a patient with a disease, said Dr. Gerdin. Disgraced tracheal transplant surgeon is handed Her global quest to find out the truth about the man who left her personal and professional life in shambles is documented in He Lied About Everything on Investigation Discovery. A High-Flying Italian Surgeons Fall From Grace, https://www.nytimes.com/2022/06/17/world/europe/macchiarini-windpipe-surgeon-deaths.html. Ciaran Lynch, born in 2000 in Ireland without a functional trachea, received a transplant on March 15, 2010, at Great Ormond Street Hospital in London. It is fitting that Macchiarinis career unravelled at the Karolinska Institute. Delaere feels the sentence is too light for what he considers a serious crime. And it needs a blood supply to connect to the patients vascular system. Largely confined to her Bronx apartment, she needed home health aides and had to quit her career as a social worker for pregnant women. Macchiarini, they claimed, wasnt really doing clinical research. He officially cleared Macchiarini of scientific misconduct, allowing merely that hed sometimes acted without due care. Thousands of people in the United States alone develop trachea problems each year from burns, birth defects, tumors and extended intubation on ventilators. Georgia Teen Vanished In South Carolina, Search Continues For North Carolina Girl, 11, Whose Parents Didnt Report Her Missing For Weeks, Where Is Ella Goodie? To some extent, they believed Macchiarini because he told them what they wanted to hear. The couple had traveled a lot, but there were some things They exchange their vows in Italy. Macchiarini was also charged with but acquitted of assault charges related to the deaths of two more of his artificial windpipe patients, an Eritrean man named Andemariam Beyene and an American man named Christopher Lyles, according to BBC News. The next morning, with the donor and Ms. Sein in adjacent rooms, a team of over 50 medical personnel assembled. Were going to show up and say, As a student, I had this idea on the back of a napkin and now were ready to go and if it fails, the patient dies and it becomes yet another example of some surgeon who thought he could solve a problem and hes created, instead, just the opposite.. But as time went on, she could not resist her connection to the dashing surgeon and she violated the number one rule of journalism: Never get involved with a person you're reporting on. Benita Alexander Thought Paolo Macchiarini Was Her Dream Man Thats something that was new to us, so we need to analyze that, Lundstrm-Kron says. Its enough to worry officials from the US Food and Drug Administration (FDA). If she talked for over five minutes, she had to stop because I couldnt breathe.. Help News from Science publish trustworthy, high-impact stories about research and the people who shape it. Faced with this public relations disaster, the Karolinska Institute immediately promised to investigate the allegations but then, within days, suddenly announced that Macchiarinis contract would not be extended. Colleagues accused him of manipulating his results, even warning of the harm caused by these so-called regenerative windpipes. Miss Universe 2021 In 2016, Vanity Fair published an expose on Paolo that uncovered even more damning evidence. Philippines The only question was how long it would take weeks, months or a few years. Gerdin says the conviction on one count still shows that health care doesnt stand above the law. (LogOut/ From November 2011 to June 2014, Paolo Macchiarini gave transplants to Christopher Lyles, Yulia Tuulik, Alexander Zozulya, Yesim Cetir, Hannah Warren (a 3-year-old), Sadiq Kanaan, and Dmitri Onogda.

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